Ghrelin, des-acyl ghrelin and obestatin: Three pieces of the same puzzle
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چکیده
منابع مشابه
Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle.
The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3 position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of physiological functions, affecting GH release, food intake, energy and glucose homeostasis, gastrointestinal, cardiovascular, pulmonary and immune function, cell proliferation and differentiation and bone physiology. N...
متن کاملRegulation of gastroduodenal motility: acyl ghrelin, des-acyl ghrelin and obestatin and hypothalamic peptides.
Real-time measurements for gut motility in conscious rats or mice combined with intracerebroventricular or intravenous injection of peptide agonists or antagonists allow us to understand the regulatory mechanism of gastrointestinal motility. Neuropeptide Y (NPY) in the arcuate nucleus in the hypothalamus stimulates the fasted motility in the duodenum, while urocortin in the paraventricular nucl...
متن کاملGhrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility
Ghrelin, des-acyl ghrelin, and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the regulatory roles of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat or mouse model. Ghrelin exerts stimulatory effects on the motility of ant...
متن کاملLack of direct effects of acyl ghrelin, des-acyl ghrelin, and obestatin on rat lower esophageal sphincter motility in vitro.
BACKGROUND Three ghrelin gene-derived peptides, acyl ghrelin, des-acyl ghrelin and obestatin, are implicated in the regulation of feeding, adipogenesis and glucose metabolism, as well as gut motility. The effects of ghrelin gene-derived peptides on lower esophageal sphincter motility, however, were unknown. METHODS We investigated the influence of acyl ghrelin, des-acyl ghrelin and obestatin ...
متن کاملMechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin.
Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been considered an inert degradation product of acyl ghrelin (AG). Recent evidence, however, indicates that DAG behaves like a separate hormone. DAG can act together with AG, can antagonize AG, and seems to have AG-indep...
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ژورنال
عنوان ژورنال: Peptides
سال: 2008
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2008.02.018